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KMID : 0381219820140040337
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Journal of RIMSK
1982 Volume.14 No. 4 p.337 ~ p.367
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Pathogenesis and Treatment of Peptic Ulcer
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Abstract
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Various approaches to show the etiologic factors of ulcerogenesis have revealed many new factors, and the successive studies would show the pathogenesis of peptic ulcer more clearly.
Chemical tests of gastric secretion and gastric mucosa were performed with animal or human. Shay rat method, Ghosh-Shild method and Lai method were used in animal test, and cysteamine ulcer observation was also used.
As one of the factors of ulcerogenesis and ulcer treatment, the effects of food on gastric secretions were observed by classification in spices, fruits and tastes. The result showed that the effects were somewhat different with each food.
The drug induced ulcers generally increased the secretion of gastric acid and pepsin, and decreased the secretion of mucoprotein.
The observation of gastric juice and gastric mucosal protein, which play important roles as protective factors, was done by resected stomach. The distribution of gasric mucosal protein showed differences with the sites of stomach and the diseases.
The distribution of gastric mucosal LDH and LDH-isozyme showed great differences with the sites of stomach. The notable one is the distribution difference between lesions and surrounding tissues of ulcer or cancer mucosa, which might be used in early diagnosis.
The effects of gastrin, secretin and CCK on secretion of gastric acid, gastric protein and mucoprotein, showed differences with the actions of each hormone. GI hormones are known to greatly influence gastric secretion and gastric mucosa proliferation, and which needs a further study.
Though the action mechanism of antiulcer drugs is even complex, gastric acid, pepsin decreasing and gastric protein, mucoprotein increasing ones were more effective in general.
Since the effective acid-neutralizing time of antacid or other regimens in Hidelberg capsule is short, it is preferable to reevaluate the drug administration method.
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